Django and Flask are both popular Python web frameworks, but they differ in their approach and complexity. Django is a full-featured framework that follows the "batteries-included" philosophy, providing a lot of built-in features and conventions for rapid development of complex web applications, including an ORM, authentication, and admin panel. Flask, on the other hand, is a lightweight microframework that gives developers more flexibility and control over the components they use, making it ideal for small to medium-sized projects or when you prefer to assemble your application from scratch. In essence, Django prioritizes convenience and speed of development, while Flask emphasizes simplicity and minimalism.